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[Reversible changes in brain volume in anorexia nervosa]

F Hentschel1, M Schmidbauer, U Detzner

  • 1Abteilung für Neuroradiologie, Zentralinstitutes für Seelische Gesundheit, Mannheim.

Zeitschrift Fur Kinder- Und Jugendpsychiatrie
|June 1, 1995
PubMed
Summary

Cranial computed tomography (CT) scans revealed significant changes in cerebrospinal fluid volume in young women with anorexia nervosa after treatment, correlating with weight recovery. These findings highlight fluid shifts and potential cerebellar pseudoatrophy in the disorder.

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Area of Science:

  • Neuroimaging
  • Radiology
  • Eating Disorders

Background:

  • Anorexia nervosa is a complex eating disorder with significant physical and psychological consequences.
  • Cerebrospinal fluid (CSF) volume alterations have been anecdotally reported in patients with anorexia nervosa.

Purpose of the Study:

  • To quantitatively assess changes in cerebrospinal fluid (CSF) volume in young women with anorexia nervosa before and after treatment.
  • To investigate the correlation between CSF volume changes and body weight recovery.
  • To explore potential differences in clinical presentation based on initial CT findings.

Main Methods:

  • Cranial computed tomography (CT) scans were performed on three groups of young women diagnosed with anorexia nervosa.
  • Volumetric and planimetric measurements were used to assess CSF volume in various brain compartments (supratentorial, extracerebral-subarachnoid, ventricles).

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  • Statistical analyses were conducted to determine the significance of changes and their correlation with body weight.

    • Main Results:

    • Statistically significant changes in CSF volume were observed, particularly in the supratentorial and extracerebral-subarachnoid spaces, with smaller changes noted in the ventricles.
    • These volumetric changes were significantly correlated with concurrent changes in body weight.
    • Two distinct patient groups emerged based on the presence or absence of cerebellar pseudoatrophy on initial CT scans, exhibiting differences in their clinical course.

    Conclusions:

    • Treatment of anorexia nervosa leads to significant, measurable changes in CSF volume, which are linked to weight restoration.
    • The presence of cerebellar pseudoatrophy on initial CT may indicate distinct pathophysiological pathways or clinical trajectories in anorexia nervosa.
    • Neuroimaging provides valuable insights into the physical sequelae of anorexia nervosa and the effects of treatment.