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[Meta-analysis of clinical trials: values and limitations]
1Service de pharmacologie clinique, Hôpital neuro-cardiologique, Lyon.
Abstract:
Meta-analysis produces reproductible, qualitative as well as quantitative overviews of available evidence. Such a synthesis is a compulsory step in conveying information on therapeutics to health care providers. Compared to more traditional approaches, meta-analysis has enough advantages to make them no longer relevant. Its limitations come from inappropriate use or less than required rigorous application of its methodology.