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Selenium and magnesium status in fibromyalgia
J Eisinger1, A Plantamura, P A Marie
1Centre Hospitalier de Toulon, France.
Magnesium Research
|December 1, 1994
Summary
Fibromyalgia patients show altered magnesium levels, specifically increased leucocyte magnesium and decreased erythrocyte magnesium. These changes may link to thiamin metabolism issues, but antioxidant and selenium levels remain normal.
Area of Science:
- Biochemistry
- Clinical Nutrition
- Medical Research
Background:
- Muscle pain is often linked to deficiencies in magnesium (Mg) and selenium (Se).
- Fibromyalgia (FM) is a chronic condition characterized by widespread musculoskeletal pain.
Purpose of the Study:
- To investigate magnesium and selenium status in patients diagnosed with fibromyalgia.
- To explore potential correlations between mineral status and metabolic abnormalities in FM.
Main Methods:
- Assessed erythrocyte (E), leucocyte (L), and serum (S) magnesium levels.
- Measured serum selenium, zinc, and vitamin B1, B2, A, and E status.
- Compared biochemical data between 22 FM patients and 23 healthy controls.
Main Results:
- Leucocyte magnesium (LMg) was significantly increased (P < 0.05) in FM patients.
- Erythrocyte magnesium (EMg) showed a slight decrease in FM patients.
- Serum selenium levels were normal and showed a slight, non-significant correlation with serum magnesium.
Conclusions:
- Abnormalities in magnesium distribution, particularly increased LMg, are observed in fibromyalgia.
- These magnesium alterations may be associated with impaired thiamin metabolism, as suggested by previous research.
- Antioxidant status and serum selenium levels appear unaffected in fibromyalgia patients.