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USF-19A, a new lipoxygenase inhibitor from Streptomyces sp
T Komoda1, Y Morimitsu, H Hirota
1Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka, Japan.
Bioscience, Biotechnology, and Biochemistry
|May 1, 1995
Abstract:
USF-19A, a soybean lipoxygenase (SBL) and human 5-lipoxygenase (5-LO) inhibitor, was isolated from Streptomyces sp. USF-19 strain. Its chemical structure was determined by spectroscopic evidence to be a new member of the antimycin antibiotic family. The IC50 value of USF-19A against 5-LO was 28.0 microM.