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Related Experiment Videos

Thrombomodulin in exercise-induced asthma

H Kanazawa1, N Kurihara, K Hirata

  • 1First Department of Internal Medicine, Osaka City University Medical School.

Internal Medicine (Tokyo, Japan)
|March 1, 1995
PubMed
Summary

Plasma thrombomodulin (TM) levels increase in asthmatic patients after exercise. Higher severity of exercise-induced asthma (EIA) correlates with greater TM level changes, suggesting pulmonary endothelial damage.

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Area of Science:

  • Biochemistry
  • Pulmonology
  • Immunology

Background:

  • Thrombomodulin (TM) is a vascular endothelium membrane protein found in human plasma.
  • Pathological functions of plasma TM are not well-defined.

Purpose of the Study:

  • To investigate plasma TM concentrations in asthmatic patients.
  • To determine the relationship between exercise challenge and plasma TM levels in exercise-induced asthma (EIA).

Main Methods:

  • Plasma TM concentrations were measured using sandwich enzyme immunoassay.
  • Monoclonal antibodies specific for human TM were utilized.
  • 19 asthmatic patients were included in the study.

Main Results:

  • Plasma TM concentration significantly increased in EIA-positive asthmatic patients following exercise challenge.

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  • A positive correlation was observed between EIA severity and the change in plasma TM levels post-exercise.
  • These findings indicate potential pulmonary endothelial damage in EIA.

    • Conclusions:

    • Exercise challenge elevates plasma TM levels in EIA-positive asthmatics.
    • Increased plasma TM suggests exercise-induced pulmonary endothelial damage in asthma.
    • Plasma TM may serve as a biomarker for endothelial injury in EIA.