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[Tuberculous lymphadenitis: a sarcoidosis-like variation]
Summary
Tuberculous lymphadenitis can mimic sarcoidosis. Mycobacterium tuberculosis and other mycobacteria may be involved in lymph node sarcoidosis, suggesting a link to infection.
Area of Science:
- Pathology
- Microbiology
- Immunohistochemistry
Context:
- Lymph node sarcoidosis diagnosis can be challenging.
- Distinguishing sarcoidosis from tuberculous lymphadenitis is crucial for appropriate treatment.
Purpose:
- To investigate the presence of Mycobacterium tuberculosis (M. TB) and mycobacteria other than tuberculosis (MOTT) in paraffin-embedded lymph node biopsies initially diagnosed as sarcoidosis.
Summary:
- Polymerase chain reaction (M. TB-PCR), immunohistochemistry (BCG-IHC), and acid-fast stain (AF) were used to detect mycobacteria in 12 lymph node samples diagnosed as sarcoidosis.
- One case with unanimous sarcoidosis diagnosis showed BCG-IHC and M. TB-PCR positivity.
- One case with majority sarcoidosis diagnosis showed AF, BCG-IHC, and M. TB-PCR positivity.
Impact:
- Findings suggest that some tuberculous lymphadenitis cases may present with sarcoidosis-like features.
- The study indicates a potential association between lymph node sarcoidosis and MOTT or M. TB infection.