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Amyloid goitre: CT and MR findings
F J Fontán1, F Cordido, J Mosquera
1Department of Radiology, Hospital Juan Canalejo, La Coruña, Spain.
Clinical Radiology
|June 1, 1995
Summary
Amyloid goitre presents as an enlarged thyroid mass. Imaging and biopsy of solid areas are crucial for diagnosing this rare condition, as cysts may lack amyloid deposits.
Area of Science:
- Endocrinology
- Pathology
- Radiology
Background:
- Amyloid goitre is a rare thyroid condition characterized by amyloid deposition.
- It can present as an enlarged thyroid mass, sometimes with cystic features.
Observation:
- Two cases of amyloid goitre are presented, characterized by enlarged thyroid masses with cystic areas.
- Computed tomography (CT) revealed high attenuation in solid portions, with moderate hypointensity on T1 and T2-weighted magnetic resonance imaging (MRI) sequences.
Findings:
- Fine needle aspiration (FNA) biopsies were initially negative for amyloid.
- Surgical specimen pathology confirmed amyloid infiltration of the thyroid interstitium and regressive colloid cysts.
Implications:
- Thyroid enlargement with cystic components in at-risk patients suggests amyloid goitre.
- Diagnostic needle biopsies should prioritize solid areas of the thyroid mass for definitive amyloid detection.