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Fibroid growth in response to high-dose progestogen
M Harrison-Woolrych1, R Robinson
1Department of Obstetrics and Gynaecology, University of Cambridge, Rosie Maternity Hospital, United Kingdom.
Objective:
To challenge the conventional belief that leiomyomata are estrogen-dependent tumors by presentation of a case report suggesting high-dose progestogen therapy is associated with a dramatic increase in size of a fibroid uterus.
Design:
Case report.
Setting:
British university hospital.
Patient:
One white woman treated with tamoxifen and high-dose megestrol acetate for breast carcinoma.
Interventions:
Megestrol acetate therapy withdrawn.
Main Outcome Measure:
Uterine size.
Results:
While taking tamoxifen and high-dose megestrol acetate, the patient suffered a dramatic increase in size of her fibroid uterus, which reversed when the progestogen was withdrawn.
Conclusion:
This case report suggests that P may be important in fibroid growth.