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Visual function in Rett syndrome

K J Saunders1, D L McCulloch, A M Kerr

  • 1Department of Vision Sciences, Glasgow Caledonian University, UK.

Developmental Medicine and Child Neurology
|June 1, 1995
PubMed
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Individuals with Rett syndrome often have significant refractive errors but possess good visual pathway function. Providing spectacle correction is likely beneficial for improving their vision.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Genetics

Background:

  • Rett syndrome is a complex neurodevelopmental disorder.
  • Visual impairments are common in individuals with profound disabilities.
  • The visual function in Rett syndrome requires further investigation.

Purpose of the Study:

  • To assess refractive error, ocular posture, and visual evoked potentials (VEPs) in individuals with Rett syndrome.
  • To determine the potential benefit of spectacle correction in this population.
  • To evaluate the function of afferent visual pathways in Rett syndrome.

Main Methods:

  • Ophthalmic examinations including refractive error assessment.
  • Pattern onset visual evoked potentials (VEPs) testing.
  • Internal and external eye examinations were conducted.

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Main Results:

  • Substantial refractive errors were prevalent in the Rett syndrome group.
  • No nystagmus or optic nerve pallor was observed; strabismus was rare.
  • Pattern-onset VEPs were recognizable and reproducible with normal latencies and amplitudes.

Conclusions:

  • Individuals with Rett syndrome demonstrate good function of afferent visual pathways.
  • Significant refractive errors in this population suggest a high likelihood of benefiting from spectacle correction.
  • Ophthalmological assessment and intervention are crucial for individuals with Rett syndrome.