Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dermatan sulfate as a potential therapeutic agent

R J Linhardt1, R E Hileman

  • 1Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa City 52242, USA.

General Pharmacology
|May 1, 1995
PubMed
Summary

Dermatan sulfate, a glycosaminoglycan, is explored for its biosynthesis, structure, and function. Its derivatives show promise as novel anticoagulant and antithrombotic therapeutics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Geometrical characteristics of eggs from 3 poultry species.

Poultry science·2021
Same author

Expression of enzymes for 3'-phosphoadenosine-5'-phosphosulfate (PAPS) biosynthesis and their preparation for PAPS synthesis and regeneration.

Applied microbiology and biotechnology·2020
Same author

Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury.

American journal of physiology. Lung cellular and molecular physiology·2020
Same author

A method for characterising human intervertebral disc glycosaminoglycan disaccharides using liquid chromatography-mass spectrometry with multiple reaction monitoring.

European cells & materials·2018
Same author

Characteristics of global organic matrix in normal and pimpled chicken eggshells.

Poultry science·2017
Same author

Characteristics of glycosaminoglycans in chicken eggshells and the influence of disaccharide composition on eggshell properties.

Poultry science·2016

Area of Science:

  • Biochemistry
  • Pharmacology
  • Molecular Biology

Background:

  • Dermatan sulfate is a key glycosaminoglycan component of proteoglycans.
  • It plays a role in various biological processes.
  • Its clinical applications are emerging.

Purpose of the Study:

  • To review the biosynthesis, structure, and biological function of dermatan sulfate proteoglycans.
  • To discuss the potential of dermatan sulfate derivatives as anticoagulant and antithrombotic agents.
  • To describe the preparation, chemistry, and structure-activity relationship of dermatan sulfate.

Main Methods:

  • Literature review of biosynthesis and structure.
  • Analysis of chemical properties and structure-activity relationships.
  • Clinical data review of dermatan sulfate applications.

Main Results:

  • Dermatan sulfate proteoglycans have diverse biological functions.
  • Dermatan sulfate and its derivatives exhibit anticoagulant and antithrombotic properties.
  • Various forms of dermatan sulfate are clinically utilized.

Conclusions:

  • Dermatan sulfate is a versatile molecule with significant therapeutic potential.
  • Further research into dermatan sulfate-based therapeutics is warranted.
  • Dermatan sulfate derivatives represent a promising class of agents for thrombosis treatment.

Related Experiment Videos