The proliferative diseases of the lymphoreticular system. Classification and pathological features of malignant...

An histogenetic classification of lymphomas is discussed, and diagnostic criteria are proposed for these neoplasms, based primarily on their histological features and assessment of the predominant cell population in the individual lymphomas. Limitations of space ane experience have precluded more comprehensive discussions on the morphology of malignant lymphomas in relation to their immunological, functional and clinical features, prognosis and response to therapeutic agents. Since we are aware that the proposed classification and histological criteria are incomplete and imperfect if the malifnant lymphomas are considered as static entities, we wish to conclude our paper by quoting a statement made by Rappaport23: '...the clinical usefulness of any classification of reticular neoplasms is limited by their often unpredictable behaviour'.