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Related Experiment Videos

Relationship between granulocyte elastase levels and perinatal infections

Y Matsuda1, H Maruyama, K Kuraya

  • 1Department of Obstetrics and Gynecology, Kagoshima City Hospital, Japan.

Gynecologic and Obstetric Investigation
|January 1, 1995
PubMed
Summary

Amniotic fluid granulocyte elastase (Af-E) effectively predicts neonatal infections. Cervical granulocyte elastase (Cx-E) and C-reactive protein (CRP) together help diagnose intrauterine infections before delivery.

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Area of Science:

  • Perinatal Medicine
  • Infectious Diseases
  • Biomarker Research

Background:

  • Perinatal infections pose significant risks to mothers and newborns.
  • Early detection of intrauterine infections is crucial for timely intervention.
  • Granulocyte elastase and C-reactive protein are potential biomarkers for infection.

Purpose of the Study:

  • To evaluate granulocyte elastase levels as predictors of perinatal infections.
  • To compare the diagnostic efficacy of cervical (Cx-E), amniotic fluid (Af-E), and gastric juice (Gj-E) elastase, alongside C-reactive protein (CRP).
  • To assess the correlation between elastase levels at different sites.

Main Methods:

  • Prospective study of 41 patients delivering within 48 hours of amniocentesis.
  • Measurement of Cx-E, serum CRP, and Af-E.

Related Experiment Videos

  • Neonatal Gj-E measured in select cases.
  • Comparative analysis of diagnostic efficacy for placental and neonatal infections, and abnormal amniotic fluid.

    • Main Results:

    • Abnormal Af-E (0.79) and placental infections (0.97) showed superior diagnostic efficacy in predicting neonatal infections compared to Cx-E (0.40) and CRP (0.49).
    • A strong correlation was observed between Af-E and Gj-E, but not between Cx-E and Af-E or Gj-E.
    • Combined Cx-E and CRP levels demonstrated the highest diagnostic efficacy (0.58) for predicting abnormal amniotic fluid.

    Conclusions:

    • Af-E is a valuable biomarker for predicting neonatal infections.
    • Elevated Cx-E and CRP levels may warrant amniocentesis for diagnosing intrauterine infections.
    • Further investigation into elastase as a predictive marker in perinatal infections is supported.