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Published on: March 9, 2022
Liver perfusion studied with ultrafast CT
M J Blomley1, R Coulden, P Dawson
1Department of Radiology, University of Chicago Hospital, IL, USA.
Journal of Computer Assisted Tomography
|May 1, 1995
Summary
Ultrafast CT can noninvasively quantify hepatic perfusion in patients with and without liver disease. This technique shows altered hepatic arterial and portal venous perfusion in cirrhosis and metastases.
Area of Science:
- Radiology
- Medical Imaging
- Hepatology
Background:
- Accurate quantification of hepatic perfusion is crucial for diagnosing and managing liver diseases.
- Noninvasive methods are preferred for patient safety and repeated assessments.
Purpose of the Study:
- To quantify absolute hepatic arterial and portal venous perfusion noninvasively using ultrafast CT.
- To compare perfusion values in healthy individuals versus patients with liver disease (cirrhosis, metastases).
Main Methods:
- Utilized ultrafast CT with intravenous contrast injection (iohexol) and saline chaser.
- Analyzed time-attenuation curves from liver, spleen, aorta, and portal vein regions of interest.
- Calculated hepatic arterial and portal venous perfusion using derived formulas.
Main Results:
- Hepatic arterial perfusion was elevated in patients with cirrhosis (0.25 ml/min/ml) and metastases (0.43 ml/min/ml) compared to controls (0.19 ml/min/ml).
- Portal venous perfusion was reduced in cirrhosis (0.43 ml/min/ml) compared to controls (0.93 ml/min/ml).
- The method demonstrated reproducibility.
Conclusions:
- Dynamic ultrafast CT is a promising technique for quantifying hepatic perfusion.
- The findings suggest potential for adapting this technique to dynamic bolus MRI for hepatic perfusion assessment.
