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Serial scintigraphy during isolated renal perfusion

D Fischer, K Hahn

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |May 22, 1976
    PubMed
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    Radioactive impulse activity, measured via Hippuran excretion, can assess kidney function after transplantation. Low Hippuran excretion at 8°C indicates renal damage, aiding in donor kidney suitability assessment.

    Area of Science:

    • Nephrology
    • Nuclear Medicine
    • Transplant Surgery

    Background:

    • Assessing donor kidney viability is crucial for successful renal transplantation.
    • Objective indicators of renal functional ability are needed for pre- and post-operative evaluation.

    Purpose of the Study:

    • To establish a quantitative standard for assessing renal functional ability using radioactive impulse activity.
    • To evaluate the utility of Hippuran excretion as an indicator of renal damage and organ suitability.

    Main Methods:

    • Utilizing radioactive impulse activity measurements, specifically Hippuran excretion, to assess renal function.
    • Employing scintigraphy for examining non-pulsatile, stored kidneys.
    • Correlating organ weight, blood flow, and scintigraphic impulse rates for initial activity estimation.

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    Main Results:

    • Hippuran excretion is temperature-dependent, measurable above 4°C and absent below 8°C.
    • Lack of Hippuran excretion at 8°C suggests significant renal damage.
    • Radioactive substances are deemed safe due to rapid washout, allowing for pre- and post-operative use.

    Conclusions:

    • Radioactive impulse activity provides a reliable method for assessing renal functional ability in transplantation.
    • Hippuran excretion measurements and scintigraphy are valuable diagnostic tools for donor kidney evaluation and management.
    • Sequential scintigrams offer critical information on organ suitability for transplantation.