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Related Experiment Videos

Extracellular pH distribution in human tumours

K Engin1, D B Leeper, J R Cater

  • 1Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

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Tumor acidity (extracellular pH) varies significantly based on cancer type and size. Histology and tumor volume are key factors influencing these pH levels in cancer research.

Area of Science:

  • Oncology
  • Biochemistry
  • Medical Physics

Background:

  • Extracellular pH (pHe) is a critical factor in tumor microenvironment.
  • Understanding pHe variations is crucial for cancer diagnosis and treatment.

Purpose of the Study:

  • To investigate the relationship between extracellular pH (pHe), tumor histology, and tumor volume.
  • To determine how different cancer types and sizes affect tumor acidity.

Main Methods:

  • Extracellular pH (pHe) was measured using needle microelectrodes in 67 tumor nodules from 58 patients.
  • Tumor histology and volume were recorded for each lesion.

Main Results:

  • Mean tumor pHe was 7.06, with significant variations between tumors.

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  • Tumor pHe differed significantly across histological types (adenocarcinoma, squamous cell carcinoma, sarcoma, melanoma).
  • Tumor pHe showed a positive correlation with tumor volume (p = 0.006).

    • Conclusions:

    • Tumor histology and tumor volume are the primary determinants of extracellular pH in tumors.
    • These findings highlight the heterogeneity of the tumor microenvironment and its influencing factors.