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Leucocyte activity in chronic venous insufficiency

G Ciuffetti1, E Mannarino, R Paltriccia

  • 1Dept. of Internal Medicine, Pathology and Pharmacology, University of Perugia, Italy.

International Angiology : a Journal of the International Union of Angiology
|December 1, 1994
PubMed
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Venous stasis in patients with varicose veins and venous hypertension impairs leukocyte filterability and increases superoxide anion production. These changes, linked to oxygen free radicals, may cause capillary plugging in venous disease.

Area of Science:

  • Vascular Biology
  • Hematology
  • Free Radical Biology

Background:

  • Venous diseases like varicose veins and venous hypertension involve complex pathophysiological mechanisms.
  • Leukocyte behavior and oxidative stress are implicated in microcirculatory disturbances.

Purpose of the Study:

  • To investigate the impact of venous stasis on leukocyte parameters and oxidative stress in patients with venous disease.
  • To differentiate the effects in varicose veins versus venous hypertension.

Main Methods:

  • Blood samples were collected from patients with varicose veins, venous hypertension, and healthy controls before, during, and after venous stasis.
  • Assessed total leukocyte count, leukocyte filterability rate (LFR), superoxide dismutase (SOD) concentrations, and granulocyte superoxide anion production.

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Main Results:

  • Venous stasis significantly increased leukocyte count and impaired LFR in both patient groups.
  • SOD levels decreased, and granulocyte oxygen free radical production dropped significantly after stasis in patients.
  • Parameters normalized post-stasis in varicose vein patients, but significant alterations persisted in venous hypertension patients.

Conclusions:

  • Impaired leukocyte rheology and altered oxygen free radical production contribute to microcirculatory damage in venous disease.
  • Venous hypertension exhibits more persistent pathophysiological changes compared to varicose veins post-stasis.