Liver enzymatic induction after repeated or prolonged stress

Changes in liver tyrosine aminotransferase induction were measured in mice after repeated or prolonged stressing. In the repeated chloroform stress variant the first impulse determines the amplitude of TAT induction; the second stress can only produce superinduction if repeated 40 minutes after the onset of the first one. In the prolonged irradiation stress variant the response was dependent on both the dose rate and duration of irradiation.