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Skeletal muscle oxygenation during constant work rate exercise

R Belardinelli¹, T J Barstow, J Porszasz

¹Department of Medicine, Harbor-UCLA Medical Center, Torrance 90509, USA.

Medicine and Science in Sports and Exercise

|April 1, 1995

Summary

The slow increase in oxygen consumption (VO2) during intense exercise is linked to reduced muscle oxygen saturation. This decline in muscle oxyhemoglobin and oxymyoglobin saturation during heavy exercise may be influenced by lactic acidosis.

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Area of Science:

Exercise Physiology
Sports Science
Muscle Metabolism

Background:

The oxygen uptake (VO2) slow component during heavy exercise remains incompletely understood.
Muscle deoxygenation dynamics during exercise are crucial for understanding VO2 kinetics.
Near-infrared spectroscopy (NIRS) allows non-invasive assessment of muscle oxygenation.

Purpose of the Study:

To investigate the relationship between the VO2 slow rise and muscle oxygen saturation (O2Hb/O2Mb) during heavy exercise.
To determine if muscle deoxygenation contributes to the VO2 slow component.

Main Methods:

Ten subjects performed cycle ergometer tests at intensities below and above their lactic acidosis threshold (LAT).
Muscle oxyhemoglobin and oxymyoglobin saturation (O2Hb/O2Mb) were measured using reflectance near-infrared spectroscopy.

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VO2 was measured continuously, and work rates were set at 20, 40, 65, and 75% of peak VO2.

Main Results:

Below LAT, muscle O2Hb/O2Mb saturation stabilized or slightly increased after an initial fall.
Above LAT, muscle O2Hb/O2Mb saturation decreased progressively over time, with a greater fall at higher work rates.
The rate of decrease in muscle O2Hb/O2Mb saturation correlated significantly with the VO2 slow rise between minutes 3 and 6 (r = -0.69).

Conclusions:

The slow component of VO2 during heavy exercise is associated with a progressive decline in muscle oxygen saturation.
This muscle deoxygenation may be facilitated by increased oxygen dissociation from hemoglobin due to tissue lactic acidosis (Bohr effect).
These findings support the hypothesis that intramuscular factors contribute significantly to VO2 kinetics during sustained heavy exercise.