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Candidal pituitary abscess: case report

R F Heary1, A H Maniker, L J Wolansky

  • 1Section of Neurological Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, USA.

Neurosurgery
|May 1, 1995
PubMed
Summary
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A rare pituitary gland fungal infection caused by Candida albicans occurred in an immunocompromised patient negative for HIV. This case highlights unusual fungal abscess presentations in the intrasellar region.

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Neurosurgery

Background:

  • Pituitary abscesses are uncommon, with fungal origins being exceptionally rare.
  • Candida albicans is an opportunistic pathogen, typically affecting immunocompromised individuals.

Observation:

  • A 36-year-old immunocompromised woman with T-cell dysfunction presented with headaches, menstrual irregularities, and diabetes insipidus.
  • Transsphenoidal surgery for a presumed pituitary adenoma revealed a culture-proven intrasellar Candida albicans abscess.

Findings:

  • This is the first reported case of an intrasellar Candida albicans abscess in a patient seronegative for human immunodeficiency virus.
  • The patient's immunocompromised state, specifically T-cell dysfunction, predisposed her to this unusual infection.

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Implications:

  • This case expands the spectrum of pituitary infections and underscores the importance of considering fungal etiologies in immunocompromised patients.
  • Highlights the need for thorough diagnostic work-up in cases of suspected pituitary lesions, especially in immunocompromised individuals.
  • Suggests that ordinarily innocuous fungi can cause severe infections in specific host conditions.