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Immunohistochemical localization of protein phosphatase isoforms in the rat cerebellum
T Hashikawa1, K Nakazawa, S Mikawa
1Laboratory for Neural Systems, Frontier Research Program, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
Neuroscience Research
|March 1, 1995
Abstract:
Protein phosphatase isoforms, PP1 gamma 1, PP1 delta, PP1 alpha and PP2A (alpha and/or beta), were immunohistochemically localized in the rat cerebellum. Purkinje cell perikarya, dendrites and spines were very PP1 gamma 1 immunoreactive. PP1 delta and PP1 alpha were perinuclear in all neurons, PP1 alpha also revealed a new cell type and PP2A was homogeneous in Purkinje cell soma and large dendrites. PP1 gamma 1 seems to be dominant for dephosphorylation at the dendritic synapses of Purkinje cells.