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Acute dynamic exercise increases fibrinolytic activity

T Rankinen1, S Väisänen, I Penttilä

  • 1Kuopio Research Institute of Exercise Medicine, Finland.

Thrombosis and Haemostasis
|February 1, 1995
PubMed
Summary
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Acute dynamic exercise significantly increases tissue plasminogen activator (tPA) and decreases plasminogen activator inhibitor (PAI) activity, with no change in fibrinogen. These effects were observed across maximal and submaximal exercise intensities.

Area of Science:

  • Exercise Physiology
  • Cardiovascular Health
  • Hemostasis

Background:

  • Dynamic exercise impacts hemostasis.
  • Understanding the effects of exercise intensity on fibrinolytic factors is crucial for cardiovascular health.
  • Tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI) are key regulators of clot breakdown.

Purpose of the Study:

  • To investigate the influence of acute dynamic exercise on plasma tPA, PAI, and fibrinogen levels.
  • To compare the effects of maximal versus submaximal exercise intensities on these hemostatic markers.

Main Methods:

  • Nine healthy men performed maximal and two submaximal (aerobic and anaerobic threshold) bicycle ergometry tests.
  • Blood samples were collected pre-exercise, immediately post-exercise, and 24 hours post-exercise.

Related Experiment Videos

  • Plasma tPA and PAI activities were measured using amidolytic assays, and fibrinogen concentration by the thrombin method.

    • Main Results:

    • tPA activity significantly increased during all exercise tests (maximal, anaerobic threshold, aerobic threshold).
    • PAI activity decreased significantly during maximal and anaerobic threshold tests, but not during the aerobic threshold test.
    • Plasma fibrinogen concentration remained unchanged throughout all exercise conditions.

    Conclusions:

    • Acute dynamic exercise, particularly at higher intensities, enhances the fibrinolytic system by increasing tPA and decreasing PAI.
    • These findings suggest a potential short-term antithrombotic effect of exercise.
    • Fibrinogen levels are not acutely affected by dynamic exercise bouts.