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Prilocaine reduces injection pain caused by propofol
1Department of Anaesthesia and Intensive Care, University Hospital of Uppsala, Sweden.
Acta Anaesthesiologica Scandinavica
|February 1, 1995
Summary
Mixing propofol with local anesthetics like prilocaine or lidocaine significantly reduces infusion pain. Ketorolac pretreatment did not alleviate propofol injection pain, suggesting a different mechanism is involved.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Propofol is a widely used anesthetic for outpatient procedures.
- Injection pain is a common and distressing side effect of propofol administration.
Purpose of the Study:
- To evaluate the efficacy of local anesthetics (prilocaine, lidocaine) in reducing propofol injection pain.
- To investigate the role of ketorolac in mitigating propofol-induced pain.
Main Methods:
- A randomized study involving 48 patients compared propofol mixed with prilocaine, lidocaine, both, or saline.
- A separate group of 22 patients received ketorolac or saline before propofol administration.
Main Results:
- Propofol mixed with local anesthetics significantly reduced injection pain compared to saline.
- Higher doses of propofol were needed when mixed with lidocaine versus saline.
- Ketorolac pretreatment did not decrease propofol injection pain.
Conclusions:
- Local anesthetics effectively reduce propofol injection pain.
- The mechanism may involve binding between propofol and local anesthetic molecules.
- Cyclooxygenase pathway inhibition is unlikely to be the primary mechanism for pain reduction.