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Perinatal asphyxia: MR findings in the first 10 days
A J Barkovich1, K Westmark, C Partridge
1Department of Radiology, University of California San Francisco 94143-0628, USA.
AJNR. American Journal of Neuroradiology
|March 1, 1995
Summary
Magnetic resonance imaging (MRI) can detect hypoxic-ischemic brain injury in neonates within 10 days of birth. This study identified distinct patterns of brain damage, aiding in early diagnosis and management of affected newborns.
Area of Science:
- Neonatal neurology
- Pediatric radiology
- Neuroimaging
Background:
- Hypoxic-ischemic (HI) brain injury is a significant cause of neonatal morbidity and mortality.
- Early detection and characterization of HI brain injury are crucial for timely intervention and improved outcomes.
Purpose of the Study:
- To evaluate the utility of Magnetic Resonance (MR) imaging in detecting hypoxic-ischemic brain injury in neonates within the first 10 days of life.
- To identify and classify the patterns of brain injury associated with hypoxia/ischemia in affected newborns.
Main Methods:
- Retrospective review of standard T1- and T2-weighted MR sequences in 20 neonates with suspected intrapartum or neonatal hypoxia/ischemia.
- Evaluation of MR images for characteristic signal changes and patterns of brain injury.
Main Results:
- Four patients had normal MR findings and were clinically healthy.
- Sixteen patients exhibited patterns of injury, including deep gray matter, cortical, periventricular white matter, or mixed involvement.
- T1 signal changes were detectable as early as 3 days post-injury, while T2 changes appeared around 6-7 days.
Conclusions:
- MR imaging is effective in demonstrating brain damage in neonates suffering from asphyxia within the first 10 days of life.
- Distinct patterns of brain injury can be identified early using MR, providing valuable diagnostic information.