Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukin-8 gene expression in chronic sinusitis

K Takeuchi1, A Yuta, Y Sakakura

  • 1Department of Otorhinolaryngology, Mie University School of Medicine, Japan.

American Journal of Otolaryngology
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Clinical efficacy of immunotherapy with house dust in the patients with perennial nasal allergy].

Arerugi = [Allergy]·2000
Same author

CFTR antisense phosphorothioate oligodeoxynucleotides (S-ODns) induce tracheo-bronchial mucin (TBM) mRNA expression in human airway mucosa.

Glycoconjugate journal·1999
Same author

Hypertonic saline nasal provocation stimulates nociceptive nerves, substance P release, and glandular mucous exocytosis in normal humans.

American journal of respiratory and critical care medicine·1999
Same author

Detection of thromboxane A2 receptor mRNA in the nasal mucosa of patients with allergic rhinitis.

Acta oto-laryngologica. Supplementum·1999
Same author

[Japanese cedar pollinosis in children in our allergy clinic].

Arerugi = [Allergy]·1999
Same author

Nasal secretion analysis in allergic rhinitis, cystic fibrosis, and nonallergic fibromyalgia/chronic fatigue syndrome subjects.

American journal of rhinology·1999
Same journal

Managing post-extubation dysphagia after prolonged intubation: A systematic review of Speech-Language Pathology (SLP) approaches.

American journal of otolaryngology·2026
Same journal

Rethinking indications for prophylactic central neck dissection in papillary thyroid microcarcinoma: A real-world retrospective study.

American journal of otolaryngology·2026
Same journal

Letter to the editor regarding "Development of a novel self-assessment tool following endoscopic sinus surgery in the management of chronic rhinosinusitis".

American journal of otolaryngology·2026
Same journal

Re: Sarcopenia and postoperative morbidity in head and neck cancer: a systematic review and meta-analysis.

American journal of otolaryngology·2026
Same journal

Epistaxis burden in hereditary hemorrhagic telangiectasia: Validation and refinement of the NOSE-HHT.

American journal of otolaryngology·2026
Same journal

An assessment of pharmacologic deep vein thrombosis prophylaxis on head and neck free flap outcomes.

American journal of otolaryngology·2026
See all related articles

Interleukin-8 (IL-8) gene expression was investigated in chronic sinusitis. The study found IL-8 mRNA in chronic sinusitis tissues, suggesting its role in the condition.

Area of Science:

  • Immunology
  • Otolaryngology
  • Molecular Biology

Background:

  • Interleukin-8 (IL-8) is a cytokine involved in neutrophil recruitment.
  • Chronic sinusitis pathogenesis may involve IL-8.
  • Understanding IL-8 gene expression is crucial for chronic sinusitis research.

Purpose of the Study:

  • To investigate Interleukin-8 (IL-8) gene expression in chronic sinusitis.
  • Utilize Northern blot analysis and RT-PCR to detect IL-8 transcripts.

Main Methods:

  • RNA extraction from maxillary mucosa, nasal polyps, and inferior turbinate tissues.
  • Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR) were performed.
  • Samples were obtained from patients with chronic sinusitis, allergic rhinitis, and hypertrophic rhinitis.

Related Experiment Videos

Main Results:

  • IL-8 mRNA was detected in maxillary mucosa but not in the inferior turbinate via Northern blot.
  • RT-PCR detected IL-8 transcripts in 45% of chronic sinusitis samples and 50% of allergic rhinitis samples.
  • Differential expression patterns of IL-8 were observed across different rhinitis conditions.

Conclusions:

  • The findings suggest that IL-8 may play a role in chronic sinusitis.
  • IL-8's involvement in neutrophil recruitment could contribute to chronic sinusitis pathogenesis.
  • Further research into IL-8's function in sinonasal inflammation is warranted.