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Consumptive coagulopathy in turkeys exposed to Pasteurella multocida
1Department of Veterinary Pathology, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
Avian Diseases
|January 1, 1995
Summary
Pasteurella multocida infection in turkeys can cause coagulopathy, indicated by increased modified Russell's viper venom time (mRVVT). This suggests a potential role for consumptive coagulopathy in the pathogenesis of fowl cholera.
Area of Science:
- Veterinary Pathology
- Coagulation Science
- Infectious Diseases
Background:
- Fowl cholera, caused by Pasteurella multocida, is a significant disease in turkeys.
- The coagulation system's role in fowl cholera pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the effect of Pasteurella multocida inoculation on the coagulation parameters in turkeys.
- To determine if consumptive coagulopathy is involved in the disease process.
Main Methods:
- Turkeys were inoculated intramuscularly or intravenously with live Pasteurella multocida.
- Modified Russell's viper venom time (mRVVT) was measured at various time points post-inoculation.
- Histopathological examination of major organs was performed to detect microthrombi.
Main Results:
- Intramuscular inoculation led to increased mRVVT in most turkeys.
- Intravenous inoculation caused a significant increase in mRVVT in all turkeys.
- No evidence of microthrombi was found in examined organs.
Conclusions:
- Pasteurella multocida infection in turkeys is associated with alterations in coagulation, specifically increased mRVVT.
- The findings suggest that consumptive coagulopathy, an excessive consumption of clotting factors, may contribute to the pathogenesis of fowl cholera.