Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High prevalence of thyroid function test abnormalities in chronic schizophrenia

S S Othman1, K Abdul Kadir, J Hassan

  • 1Department of Medicine, National University of Malaysia, Jalan Raja Muda, Kuala Lumpur.

The Australian and New Zealand Journal of Psychiatry
|December 1, 1994
PubMed
Summary

Chronic schizophrenia patients show increased thyroid antibodies and varied thyroid function abnormalities, suggesting potential hypothalamo-pituitary thyroid axis and peripheral regulation issues. Further research is needed to clarify these thyroid status findings.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Closed-loop vasopressor systems for hemodynamic stability during cesarean delivery and maternal and neonatal outcomes: a systematic review and meta-analysis.

International journal of obstetric anesthesia·2025
Same author

Epidemiology, risk factor and R<sub>0</sub> investigation of an outbreak of lumpy skin disease in cattle in Punjab, India.

Preventive veterinary medicine·2025
Same author

The Impact of Aging Oral Health on Long COVID-19.

Journal of dental research·2025
Same author

Reversible zoonotic transmission of TB from humans to dairy cattle.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2025
Same author

Structural Evolution of GaO<sub></sub>-Shell and Intermetallic Phases in Ga-Pt Supported Catalytically Active Liquid Metal Solutions.

The journal of physical chemistry letters·2024
Same author

Is Brucella excreted in cattle faeces? - Evidence from Punjab, India.

Comparative immunology, microbiology and infectious diseases·2023

Area of Science:

  • Endocrinology
  • Psychiatry
  • Immunology

Background:

  • Chronic schizophrenia is a complex mental disorder with potential links to various physiological abnormalities.
  • Thyroid dysfunction is increasingly recognized as a potential comorbidity in psychiatric conditions.

Purpose of the Study:

  • To investigate the prevalence of thyroid antibodies and thyroid function test abnormalities in patients with chronic schizophrenia.
  • To compare thyroid antibody prevalence in schizophrenia patients with healthy blood donors.
  • To explore the relationship between thyroid status and thyroid hormone levels in this population.

Main Methods:

  • Assessed thyroid status in 249 chronic schizophrenia patients (136 males, 113 females).
  • Measured thyroid antibodies (TAb) and thyroid hormone levels (TSH, T4, FT4, FT3).

Related Experiment Videos

  • Compared TAb prevalence with healthy control groups (152 females, 449 males).

    • Main Results:

    • Thyroid antibodies (TAb) were found in 20% of patients, significantly higher than in healthy controls (28% vs 13% in females, 14% vs 7% in males).
    • Thyroid function abnormalities were common: 60% normal, 5% elevated TSH, 17% low TSH among 183 patients with hormone measurements.
    • Thyroid hormones (T4, FT4, FT3) were lower in patients with abnormal TSH; 23% of patients with normal TSH had low T3.

    Conclusions:

    • A spectrum of thyroid function test abnormalities exists in chronic schizophrenia.
    • These abnormalities may involve central (hypothalamo-pituitary thyroid axis) and peripheral regulation.
    • The clinical significance of thyroid antibodies and biochemical abnormalities in chronic schizophrenia requires further investigation.