Related Experiment Videos
Regulation of FGF-4 enhancer activity by transcription factor NF-Y
M Bryans1, J M Lucas, T J Knobloch
1Department of Hematology and Oncology, Ohio State University, Columbus 43210, USA.
Biochemical and Biophysical Research Communications
|June 15, 1995
Abstract:
Regulation of FGF-4 gene expression is controlled both by elements in the promoter and by an enhancer domain located in the untranslated region of the third exon. We have determined that transcription factor NF-Y binds to the FGF-4 promoter. We further show by mutational analysis that binding of NF-Y is essential for FGF-4 enhancer activity but has minimal effect on activity of the FGF-4 promoter alone.