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Trisomy 11: an association with stem/progenitor cell immunophenotype

M L Slovak1, S T Traweek, C L Willman

  • 1Department of Cytogenetics, City of Hope National Medical Center, Duarte, California 91010, USA.

British Journal of Haematology
|June 1, 1995
PubMed
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Trisomy 11 in acute myeloid leukaemia (AML) is associated with a stem cell immunophenotype and poor treatment response. This finding suggests AML with trisomy 11 has an unfavorable prognosis, requiring further investigation.

Area of Science:

  • Hematology
  • Oncology
  • Cytogenetics

Background:

  • The clinicopathological features and prognostic significance of acute myeloid leukaemia (AML) with trisomy 11 remain largely unknown.
  • Trisomy 11 is a rare chromosomal abnormality in AML, necessitating further characterization.

Purpose of the Study:

  • To describe the clinicopathological features of adult AML cases with trisomy 11.
  • To evaluate the prognostic significance of trisomy 11 in AML.

Main Methods:

  • Retrospective analysis of 15 adult AML cases with trisomy 11.
  • Karyotyping, immunophenotyping (HLA-DR, CD34, CD15, CD33, CD13, CD19), and MLL gene rearrangement analysis were performed.

Main Results:

  • Trisomy 11 occurred as the sole anomaly in 8 cases and with other aberrations in 7 cases.

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  • Leukaemic blasts exhibited a stem cell immunophenotype; trilineage dysplasia was observed in 6 cases.
  • Patients achieved short first complete remission (mean 8 months) with a poor prognosis, irrespective of additional cytogenetic abnormalities.

    • Conclusions:

    • AML with trisomy 11 is characterized by a stem/progenitor cell immunophenotype.
    • This subtype shows a poor response to standard chemotherapy and an unfavorable prognosis.
    • Further research into novel therapeutic strategies for trisomy 11 AML is warranted.