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Hepatocyte proliferation in silicotic rat liver after partial hepatectomy
1Department of Physiology, Faculty of Medicine, Charles University, Hradec Králové, Czech Republic.
Physiological Research
|January 1, 1994
Abstract:
Liver silicosis was induced in rats by an intravenous injection of silica particles. The presence of silicotic granulomas in the liver lowered the initial response of hepatocytes to partial (37%) hepatectomy and slowed down the decline in the number of dividing cells 6 days after the stimulus, but did not affect significantly the total number of mitotic cells.