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Lamellar-phase polymorphism in interdigitated bilayer assemblies

J T Mason1, R E Cunningham, T J O'Leary

  • 1Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.

Biochimica Et Biophysica Acta
|May 24, 1995
PubMed
Summary
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Low-temperature incubation transforms small liposomes of 1-octadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine (C(18)C(10)PC) into planar sheets, altering their gel-phase transition temperature. This reveals insights into phospholipid bilayer behavior and interdigitated phase transitions.

Area of Science:

  • Biophysics
  • Materials Science
  • Physical Chemistry

Background:

  • Phospholipid bilayers exhibit diverse phases influencing membrane properties.
  • 1-octadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine (C(18)C(10)PC) forms mixed-interdigitated gel-phase bilayers.
  • Liposome size and morphology can affect bilayer phase transitions.

Purpose of the Study:

  • To investigate the thermotropic behavior of C(18)C(10)PC bilayers.
  • To understand the structural basis for observed phase transitions.
  • To explore the role of phospholipid geometry in interdigitated bilayer formation.

Main Methods:

  • Differential scanning calorimetry (DSC) for phase transition analysis.
  • Electron microscopy for structural characterization.

Related Experiment Videos

  • Preparation and incubation of C(18)C(10)PC liposome suspensions.

    • Main Results:

    • Freshly prepared C(18)C(10)PC liposomes show a single phase transition at 14.6°C.
    • Low-temperature incubation (<2°C) induces an additional transition at 17.9°C.
    • Liposomes <0.2 microns convert to planar lamellar sheets, responsible for the higher transition temperature.

    Conclusions:

    • Liposome size and morphology significantly impact the thermotropic behavior of C(18)C(10)PC bilayers.
    • Planar lamellar sheets exhibit distinct phase transition properties compared to liposomes.
    • Findings suggest reversibility of interdigitated gel to liquid-crystalline phase transitions is influenced by phospholipid structure and aggregation state.