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Corticosteroid receptor antagonists: a current perspective

W Sutanto1, E R de Kloet

  • 1Division of Pharmacology, Sylvius Laboratories, Leiden, The Netherlands.

Pharmacy World & Science : PWS
|March 24, 1995
PubMed
Summary
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This review covers mineralocorticoid and glucocorticoid receptor antagonists, detailing their mechanisms and therapeutic uses. It highlights available and novel compounds for various clinical applications.

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Mineralocorticoid and glucocorticoid receptors are key regulators of physiological processes.
  • Steroid hormones acting on these receptors have significant effects in the brain and periphery.

Purpose of the Study:

  • To review antagonists targeting mineralocorticoid and glucocorticoid receptors.
  • To describe the concepts and mechanisms of these receptor systems.
  • To present examples of antimineralocorticoids and antiglucocorticoids with their pharmacological and clinical profiles.

Main Methods:

  • Literature review of existing and novel antagonists.
  • Description of receptor system concepts and steroid mechanisms.
  • Compilation of pharmacological data and clinical applications.

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Main Results:

  • Overview of mineralocorticoid and glucocorticoid receptor antagonist classes.
  • Explanation of steroid action mechanisms in central and peripheral systems.
  • Presentation of selected antagonists, including their properties and uses.

Conclusions:

  • Antagonists of mineralocorticoid and glucocorticoid receptors represent important therapeutic agents.
  • Understanding receptor systems and steroid mechanisms is crucial for drug development.
  • Further research into novel antagonists may offer expanded clinical benefits.