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Histopathological study on the effect of octreotide
S Yokoyama1, M Goto, T Asakura
1Department of Neurosurgery, Faculty of Medicine, Kagoshima University.
Noshuyo Byori = Brain Tumor Pathology
|March 1, 1995
Summary
Octreotide increases lysosomes by retaining growth hormone (GH) secretory granules. This mechanism explains how octreotide lowers GH levels in patients.
Area of Science:
- Endocrinology
- Cell Biology
Background:
- Octreotide is a somatostatin analog used to treat conditions involving excess growth hormone (GH).
- The precise cellular mechanism by which octreotide lowers GH levels remains incompletely understood.
Purpose of the Study:
- To elucidate the mechanism of action of octreotide in regulating growth hormone secretion.
- To investigate the cellular changes associated with octreotide treatment.
Main Methods:
- Quantitative electron microscopy was employed to assess cellular structures.
- Postembedding immunogold technique was utilized to localize growth hormone within cells.
Main Results:
- Electron microscopy revealed a marked increase in lysosomes in patients treated with octreotide.
- Growth hormone was localized to secretory granules, but not to lysosomes, using immunogold labeling.
Conclusions:
- Octreotide treatment leads to the retention of growth hormone secretory granules.
- The subsequent increase in lysosomes is a consequence of granule retention, contributing to the GH-lowering effect of octreotide.