Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Mitral valve prolapse

E D Wigle, H Rakowski, N Ranganathan

Annual Review of Medicine

|January 1, 1976

Summary

This summary is machine-generated.

Mitral valve prolapse (MVP) is increasingly recognized, often linked to myxomatous degeneration and potential left ventricular dysfunction. Further research is needed to understand its causes and relationship to symptoms and arrhythmias.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cardiomegaly in a young infant.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015

Same author

Quantification of myocardial iron deposition by two-dimensional speckle tracking in patients with β-thalassaemia major and Blackfan-Diamond anaemia.

Heart (British Cardiac Society)·2011

Same author

Commentaries.

Canadian Medical Association journal·2010

Same author

Outcomes after "unroofing" of a myocardial bridge of the left anterior descending coronary artery in children with hypertrophic cardiomyopathy.

Pediatric cardiology·2004

Same author

Mutations of the beta myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis.

Heart (British Cardiac Society)·2003

Same author

Contrast-enhanced quantitation of left ventricular ejection fraction: what is the best method?

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2001

Same journal

Dupilumab Emerges as an Effective Antibody Therapy for Eosinophilic Esophagitis.

Annual review of medicine·2026

Same journal

CAR T Cell Toxicities and Emerging Treatment Strategies.

Annual review of medicine·2026

Same journal

Transthyretin Amyloid Cardiomyopathy: A Rapidly Evolving Landscape.

Annual review of medicine·2026

Same journal

Accessibility of Somatic Genetic Testing for Cancer Treatment Decisions.

Annual review of medicine·2026

Same journal

Diffuse Parenchymal Lung Disease: Updates in Pathophysiology and Management.

Annual review of medicine·2026

Same journal

Revascularization for Ischemic Cardiomyopathy: Disproving the 45-Year-Old Concept of Hibernating Myocardium.

Annual review of medicine·2026

See all related articles

Area of Science:

Cardiology
Valvular Heart Disease
Genetics

Background:

Mitral valve prolapse (MVP) is a condition of increasing recognition, characterized by myxomatous degeneration of the mitral valve leaflets.
Idiopathic MVP predominantly affects young females and can be associated with symptoms like chest pain, dyspnea, fatigue, and syncope.
Left ventricular dysfunction is noted in some MVP cases, prompting consideration of associated cardiomyopathy.

Purpose of the Study:

To review the current understanding of mitral valve prolapse (MVP), focusing on its idiopathic form.
To highlight diagnostic methods, clinical presentations, and potential complications of MVP.
To identify unanswered questions regarding the etiology and pathophysiology of idiopathic MVP.

Main Methods:

Related Experiment Videos

Review of clinical findings, including characteristic nonejection clicks and late systolic murmurs.

Diagnostic confirmation via echocardiography and ventricular cineangiography.

Differential diagnosis considering MVP associated with other conditions like Marfan syndrome and hypertrophic cardiomyopathy.

Main Results:

MVP diagnosis is supported by characteristic physical exam findings and confirmed with imaging.
Complications include infective endocarditis, mitral insufficiency, and ventricular arrhythmias.
Distinguishing idiopathic MVP from secondary causes is crucial for management.

Conclusions:

While descriptive knowledge of MVP has advanced, the nature of myxomatous degeneration and its link to ventricular dysfunction and symptoms remain unclear.
Further research is essential to address the etiology, pathophysiology, and optimal management of idiopathic mitral valve prolapse.
Understanding the relationship between valve pathology, left ventricular function, and clinical manifestations is critical.