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Some determinants of whole-gut transit time: a population-based study
C S Probert1, P M Emmett, K W Heaton
1University Department of Medicine, Bristol Royal Infirmary, UK.
Summary
Whole-gut transit time, linked to gallstones and bowel cancer risk, is influenced by lifestyle. Alcohol speeds transit in both sexes, while oral contraceptives slow it in women. Dietary fiber intake also impacts transit time.
Area of Science:
- Gastroenterology
- Nutritional Science
- Epidemiology
Background:
- Slow whole-gut transit time is a potential risk factor for gallstones and bowel cancer.
- The determinants of whole-gut transit time remain largely unknown.
- Understanding these determinants is crucial for public health and disease prevention strategies.
Purpose of the Study:
- To identify the determinants of whole-gut transit time in a community-based population.
- To investigate the influence of age, sex hormones, oral contraceptive use, alcohol consumption, and dietary factors on transit time.
Main Methods:
- A community-based study involving 884 women and 677 men.
- Transit time estimation through prospective stool examination and bowel habit questionnaires.
- Dietary intake and alcohol consumption assessed using validated food frequency questionnaires.
Main Results:
- Alcohol consumption significantly quickened transit time in both men and women.
- Oral contraceptive use was associated with a longer transit time in women.
- Body mass index, soluble/insoluble non-starch polysaccharide (NSP) intake, and specific food groups (potatoes, cooked fruit, pulses, bread) also significantly affected transit time.
Conclusions:
- Lifestyle factors, including alcohol intake, oral contraceptive use, and dietary fiber, significantly influence whole-gut transit time.
- Findings suggest potential mechanisms linking diet and lifestyle to gastrointestinal health and disease risk.
- Further research can explore targeted interventions to optimize transit time.