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Critical illness poly-neuropathy following severe hyperpyrexia

P T Wilmshurst1, D F Treacher, P L Lantos

  • 1Huddersfield Royal Infirmary, UK.

QJM : Monthly Journal of the Association of Physicians
|May 1, 1995
PubMed
Summary

Severe hyperpyrexia, or high fever, may cause critical illness polyneuropathy. This neurological disorder can develop even when fever is secondary to other conditions like phaeochromocytoma or sepsis.

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Area of Science:

  • Neurology
  • Critical Care Medicine
  • Endocrinology

Background:

  • Critical illness polyneuropathy (CIP) is a common complication in critically ill patients.
  • The exact causes and risk factors for CIP are still being investigated.
  • Hyperpyrexia, or extremely high fever, is a recognized but not fully understood factor in critical illness.

Observation:

  • Two patients with severe hyperpyrexia were studied.
  • In one patient, fever was caused by a phaeochromocytoma.
  • In the other patient, fever was due to sepsis.

Findings:

  • Both patients developed critical illness polyneuropathy (CIP).
  • The development of CIP occurred following the period of severe hyperpyrexia.
  • This suggests a potential link between high fever and CIP.

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Implications:

  • Severe hyperpyrexia may be an independent etiological factor for critical illness polyneuropathy.
  • Further research is warranted to explore the mechanisms linking high fever and CIP.
  • Clinicians should consider fever management strategies in critically ill patients to potentially mitigate CIP risk.