Related Experiment Videos
On the cellular localization and distribution of carbonic anhydrase II immunoreactivity in the rat brain
L F Agnati1, B Tinner, W A Staines
1Department of Human Physiology, University of Modena, Italy.
Brain Research
|April 3, 1995
Abstract:
Evidence is provided that carbonic anhydrase-II is localized in the central nervous system to wide spread systems of oligodendrocytes and restricted astroglia populations, involving both fiber bundles and neuropil. It is suggested that CO2 formed in activated axons may, via carbonic anhydrase-II, give rise to protons controlling the excitability of surrounding neuropil. Thus, CO2 may represent an important, highly diffusible, signal in brain, involved in the tonic control of neuronal activity.