Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Proteoglycans in the developing brain]

A Oohira1

  • 1Department of Perinatology and Neuroglycoscience, Aichi Prefectural Colony, Kasugai, Japan.

Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Stem cell therapies CNS diseases--can they save babies with brain injuries?].

No to hattatsu = Brain and development·2011
Same author

Activity-dependent remodeling of chondroitin sulfate proteoglycans extracellular matrix in the hypothalamo-neurohypophysial system.

Neuroscience·2010
Same author

Construction of perineuronal net-like structure by cortical neurons in culture.

Neuroscience·2005
Same author

Neuronal expression of the chondroitin sulfate proteoglycans receptor-type protein-tyrosine phosphatase beta and phosphacan.

Neuroscience·2005
Same author

Transient expression of juvenile-type neurocan by reactive astrocytes in adult rat brains injured by kainate-induced seizures as well as surgical incision.

Neuroscience·2002
Same author

Upregulated expression of N-syndecan, a transmembrane heparan sulfate proteoglycan, in differentiated neural stem cells.

Brain research·2001

Researchers identified novel brain proteoglycans, including neurocan, which regulates neurite outgrowth and is linked to neuronal activity. Other proteoglycans, like 6B4-PG and growth-can, are involved in specific neuronal circuits and synapse formation, highlighting their roles in brain development.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Glycobiology

Context:

  • The brain exhibits diverse proteoglycan species crucial for neural development.
  • Understanding these molecules is key to deciphering neural network formation.

Purpose:

  • To identify and characterize novel proteoglycans in the developing rat brain.
  • To investigate the roles of specific proteoglycans in neuronal development and function.

Summary:

  • Monoclonal antibodies identified neurocan (a soluble chondroitin sulfate proteoglycan) that regulates neurite outgrowth by binding to neuronal cell adhesion molecules.
  • Neurocan expression is influenced by neuronal activity in developing brain regions.
  • A cerebellar-specific chondroitin sulfate proteoglycan (6B4-PG) and a membrane-bound heparan sulfate proteoglycan (growth-can) are involved in specific neuronal circuits and synapse formation, respectively.

Related Experiment Videos

Impact:

  • This study reveals multiple neuronal proteoglycans involved in various stages of brain development and neuronal network formation.
  • Future research in proteoglycan molecular cloning and glycobiology will further elucidate their pivotal roles in neural development.