[The effects of progestin on the bone metabolism in postmenopausal women]

Thirty postmenopausal women, including 26 with history of hysterectomy and bilateral salpingooophorectomy due to uterine myoma and 4 with natural menopause without any diseases were randomly allocated into two groups. Fifteen subjects received medroxyprogesterone acetate (MPA) 10 mg twice daily for three months, the other 15 received both MPA 10 mg twice daily and cyclopentylethinyl estriol (CEE3) 5 mg once a month for three months. Fasting urinary calcium/creatinine (Ca/Cr) and hydroxyproline/creatinine (OHpr/Cr) ratio, serum calcitonon (CT) and alkaline phosphatase (AKP) concentrations were measured before and after treatment in all subjects. The results showed that in both groups, the fasting urinary Ca/Cr and OHpr/Cr ratio reduced significantly, while serum CT and AKP increased significantly after treatment. The changes of these parameters were not significantly different between these two groups. These data indicated that progestin alone appeared effective in preventing postmenopausal osteoporosis.