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Rabies virus vaccines

L G Schneider1

  • 1WHO Collaborating Centre for Rabies Surveillance and Research, Tübingen, Germany.

Developments in Biological Standardization
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Oral vaccination using SAD B19 effectively eliminates wildlife rabies in foxes and raccoon dogs. This extensive field research confirms the vaccine

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Area of Science:

  • Veterinary Virology
  • Wildlife Disease Ecology
  • Immunology

Background:

  • Rabies poses a significant threat to wildlife, domestic animals, and humans.
  • Extensive research on fox behavior, bait uptake, and vaccine efficacy has been conducted.
  • Previous studies have explored population dynamics following oral vaccination.

Purpose of the Study:

  • To evaluate the efficacy of oral immunisation strategies for rabies elimination in foxes.
  • To assess the long-term impact of oral rabies vaccination on wildlife populations.
  • To validate the use of the SAD B19 rabies vaccine in extensive field trials.

Main Methods:

  • Long-term field trials involving oral vaccination of foxes.
  • Monitoring bait uptake and vaccine efficacy in target wildlife populations.

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  • Behavioral studies of foxes in relation to vaccination campaigns.

    • Main Results:

    • The SAD B19 oral rabies vaccine has demonstrated high efficacy in eliminating rabies among foxes and raccoon dogs.
    • European field trials represent the most extensive testing of a wildlife rabies vaccine to date.
    • Successful oral immunisation led to the complete disappearance of rabies in domestic animals and humans in affected areas.

    Conclusions:

    • Oral immunisation of foxes with SAD B19 is a highly effective strategy for controlling and eliminating wildlife rabies.
    • The success in European field trials suggests a sustainable method for preventing rabies transmission.
    • Eliminating wildlife rabies through vaccination significantly benefits public health and animal welfare.