Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aspirin sensitive rhinosinusitis and asthma

M L Kowalski1

  • 1Department of Clinical Immunology and Allergy, Medical Academy of Lödz, Poland.

Allergy Proceedings : the Official Journal of Regional and State Allergy Societies
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A European-Japanese study on peach allergy: IgE to Pru p 7 associates with severity.

Allergy·2023
Same author

The GALEN rhinosinusitis cohort: chronic rhinosinusitis with nasal polyps affects health-related quality of life.

Rhinology·2019
Same author

The Global Allergy and Asthma European Network (GALEN rhinosinusitis cohort: a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps.

Rhinology·2018
Same author

Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the MASK study.

Allergy·2018
Same author

Treatment of allergic rhinitis using mobile technology with real-world data: The MASK observational pilot study.

Allergy·2018
Same author

CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis: a SUNFRAIL report.

Clinical and translational allergy·2017

Aspirin-sensitive asthma and rhinosinusitis mechanisms remain unclear, despite increased incidence. Research explores leukotriene pathways and cellular changes, with aspirin desensitization showing potential therapeutic benefits.

Area of Science:

  • Immunology
  • Pharmacology
  • Respiratory Medicine

Background:

  • Aspirin-sensitive asthma is a recognized clinical condition with an obscure underlying mechanism.
  • Recent studies suggest a higher incidence, potentially affecting up to 40% of steroid-dependent asthmatics.
  • Identifying aspirin-sensitive individuals can be achieved through oral or bronchial aspirin challenge.

Purpose of the Study:

  • To investigate the obscure mechanisms behind aspirin-sensitive asthma and rhinosinusitis.
  • To explore the role of leukotrienes and cellular abnormalities in the pathogenesis of this syndrome.
  • To evaluate the potential of aspirin desensitization as a therapeutic option.

Main Methods:

  • Utilizing aspirin challenge tests (oral and bronchial) to identify sensitive individuals.

Related Experiment Videos

  • Analyzing leukotriene production and sensitivity (e.g., leukotriene E4, C4) in affected patients.
  • Investigating cellular activation and metabolic abnormalities in eosinophils, platelets, and monocytes.

    • Main Results:

    • Aspirin-induced reactions are associated with increased vascular permeability.
    • Aspirin-sensitive individuals exhibit altered leukotriene E4 production and heightened sensitivity to inhaled leukotriene E4.
    • Nasal secretions show enhanced leukotriene C4 concentrations post-aspirin challenge in sensitive individuals, though non-sensitive patients also show this.
    • Eosinophil activation and metabolic abnormalities in platelets and monocytes are observed in aspirin-sensitive rhinosinusitis.

    Conclusions:

    • The precise pathogenic defect in aspirin-sensitive asthma and rhinosinusitis remains elusive.
    • Leukotriene pathway alterations and cellular dysfunctions are implicated but not fully understood.
    • Aspirin desensitization presents a viable treatment strategy for select patients with severe aspirin-sensitive rhinosinusitis and asthma.