Search research articles

Search research articles

Related Experiment Videos

Immunosuppressive therapy for asthma

¹Department of Medicine, University of Washington, Seattle 98104, USA.

Allergy Proceedings : the Official Journal of Regional and State Allergy Societies

|March 1, 1995

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Molecular cytogenetic analysis of recurrent unbalanced t(11;17) in neuroblastoma.

Cancer genetics and cytogenetics·2004

Same author

Evolution of unbalanced gain of distal chromosome 2p in neuroblastoma.

Cytogenetic and genome research·2004

Same author

Are gains of chromosomal regions 7q and 11p important abnormalities in neuroblastoma?

Cancer genetics and cytogenetics·2003

Same author

Genetic abnormalities in a pre and post-chemotherapy hepatoblastoma.

Cytogenetics and cell genetics·2002

Same author

Isolation and analysis of thermotolerant mutants of wheat.

Journal of experimental botany·2000

Same author

Coordinate deletion of chromosome 3p and 11q in neuroblastoma detected by comparative genomic hybridization.

Cancer genetics and cytogenetics·2000

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Researchers are exploring alternatives to corticosteroids for severe asthma management. Methotrexate is a proven substitute, cyclosporine shows promise, but troleandomycin (TAO) is unsuitable.

Area of Science:

Pulmonology and Pharmacology
Immunology and Rheumatology

Background:

Corticosteroids are standard for severe asthma but have side effects.
There is a clinical need for safer, effective alternatives.
Rheumatology and dermatology have experience with corticosteroid-sparing agents.

Purpose of the Study:

To review recent findings on alternative therapies for severe bronchial asthma.
To evaluate the efficacy and safety of agents investigated as corticosteroid substitutes.

Main Methods:

Review of clinical trials and pharmacological studies.
Analysis of data on methotrexate, cyclosporine, and troleandomycin (TAO).

Main Results:

Methotrexate is established as an effective corticosteroid alternative through multiple double-blind trials.

Related Experiment Videos

Cyclosporine demonstrates promising results in preliminary investigations.

Troleandomycin (TAO) has been found inappropriate for replacing corticosteroids in asthma management.

Conclusions:

Methotrexate is a viable alternative for severe asthma.
Cyclosporine warrants further investigation as a potential corticosteroid-sparing agent.
Troleandomycin (TAO) should not be considered a substitute for corticosteroids in asthma treatment.