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Larynx injected with polytef paste
Archives of Otolaryngology (Chicago, Ill. : 1960)
|July 1, 1976
Summary
Intracordal polytef injection improved swallowing and voice in a lung cancer patient with laryngeal paralysis. Histology showed a benign foreign body reaction, with no signs of intolerance or carcinogenicity.
Area of Science:
- Laryngology
- Oncology
- Pathology
Background:
- Laryngeal paralysis can cause significant dysphonia and dysphagia.
- Treatment options for vocal fold immobility are limited, especially in patients with advanced cancer.
Observation:
- A patient with inoperable lung cancer and left-sided laryngeal paralysis received intracordal polytef injection.
- Symptoms including dysphonia, dysphagia, aspiration, and weak cough improved post-injection.
- A second patient experienced polytef extrusion misinterpreted as a thyroid nodule.
Findings:
- Histopathology revealed a bland, chronic foreign body reaction to the polytef implant, characterized by giant cells and lymphocytes.
- No acute inflammatory signs, intolerance, or carcinogenicity were observed in the first case.
- The second case showed a more acute foreign body reaction after 11 months, with extrusion over the thyroid gland.
Implications:
- Intracordal polytef injection offers a viable treatment for paralytic dysphonia in advanced cancer patients.
- Monitoring for potential implant extrusion and varied tissue reactions is recommended.
- Polytef appears to be a safe, non-carcinogenic implant material for laryngeal rehabilitation.