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Larynx injected with polytef paste

C B Stephens, G E Arnold, J W Stone

    Archives of Otolaryngology (Chicago, Ill. : 1960)
    |July 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Intracordal polytef injection improved swallowing and voice in a lung cancer patient with laryngeal paralysis. Histology showed a benign foreign body reaction, with no signs of intolerance or carcinogenicity.

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    Area of Science:

    • Laryngology
    • Oncology
    • Pathology

    Background:

    • Laryngeal paralysis can cause significant dysphonia and dysphagia.
    • Treatment options for vocal fold immobility are limited, especially in patients with advanced cancer.

    Observation:

    • A patient with inoperable lung cancer and left-sided laryngeal paralysis received intracordal polytef injection.
    • Symptoms including dysphonia, dysphagia, aspiration, and weak cough improved post-injection.
    • A second patient experienced polytef extrusion misinterpreted as a thyroid nodule.

    Findings:

    • Histopathology revealed a bland, chronic foreign body reaction to the polytef implant, characterized by giant cells and lymphocytes.
    • No acute inflammatory signs, intolerance, or carcinogenicity were observed in the first case.

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  • The second case showed a more acute foreign body reaction after 11 months, with extrusion over the thyroid gland.

    • Implications:

    • Intracordal polytef injection offers a viable treatment for paralytic dysphonia in advanced cancer patients.
    • Monitoring for potential implant extrusion and varied tissue reactions is recommended.
    • Polytef appears to be a safe, non-carcinogenic implant material for laryngeal rehabilitation.