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Decrease of thyroid hormones in patients with familial hypercholesterolemia during dextran sulphate low-density

S Pintus¹, P Pintus, C Piras

¹Dismetabolic Diseases Centre, St. Michele Hospital, Cagliari, Italy.

Journal of Clinical Apheresis

|January 1, 1994

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Dextran sulfate adsorption (DSA) in familial hypercholesterolemia (FH) patients lowers thyroid hormones. This indicates FH patients have more thyroid hormones bound to lipoproteins.

Area of Science:

Endocrinology
Cardiovascular Science
Lipid Metabolism

Background:

Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of low-density lipoproteins (LDL).
Thyroid hormones, triiodothyronine (T3) and thyroxine (T4), circulate in plasma primarily bound to proteins, with a smaller fraction bound to lipoproteins.
The expanded lipoprotein pool in FH patients may influence thyroid hormone binding.

Purpose of the Study:

To investigate the impact of LDL removal on plasma thyroid hormone levels in FH patients.
To explore the relationship between lipoprotein levels and thyroid hormone distribution in FH.

Main Methods:

Utilized dextran sulfate adsorption (DSA) to remove LDL from plasma in FH patients.
Measured plasma concentrations of T3 and T4 before and after DSA treatment.

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Main Results:

DSA treatment led to a significant decrease in plasma T3 levels (-28.5%) and T4 levels (-18.7%).
The reduction in thyroid hormones suggests a substantial portion was associated with the removed LDL fraction.

Conclusions:

FH patients exhibit an increased proportion of thyroid hormones bound to lipoproteins compared to the general population.
LDL plays a significant role in the transport and distribution of thyroid hormones in FH.