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Dermatomyofibroma: report of two cases
1Department of Pathology, University of Texas Medical Branch, Galveston 77555-0588.
Journal of Cutaneous Pathology
|August 1, 1994
Summary
Dermatomyofibroma, a benign skin growth of fibroblasts, is detailed in two new cases of young women. These lesions showed no recurrence, supporting its distinct histological identity from other skin tumors.
Area of Science:
- Dermatopathology
- Surgical Pathology
- Oncology
Background:
- Dermatomyofibroma is a recently identified benign acquired cutaneous proliferation.
- It originates from fibroblasts and myofibroblasts within the skin.
Observation:
- Two new cases of dermatomyofibroma in young women are presented.
- Lesions were small (0.5 and 1.0 cm) and located on the breast and upper back.
- Follow-up showed no recurrence at 8 months and 3 years.
Findings:
- Histologically, lesions showed uniform spindle cells in fascicles, minimal atypia, and absent mitotic figures.
- Immunohistochemistry revealed vimentin and muscle actin positivity, with negativity for desmin, S-100, factor XIIIa, and CD34.
- Electron microscopy confirmed myofibroblast presence, aiding differential diagnosis from other fibroblastic tumors.
Implications:
- This study supports the histological distinction of dermatomyofibroma from other fibroblastic skin proliferations.
- Accurate diagnosis is crucial for appropriate patient management and prognosis.
- Further research may elucidate the specific etiology and behavior of dermatomyofibroma.