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Chromatin structure and function in proliferating cells

R Baserga, C Nicolini

    Biochimica Et Biophysica Acta
    |April 30, 1976
    PubMed
    Summary
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    Chromatin structure and function are highly sensitive to cell proliferation states, with detectable differences across cell cycle phases. These changes, observed in intact nuclei and partially reversible with salt extraction, offer insights into chromatin organization.

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Biochemistry

    Background:

    • Chromatin structure and function are dynamic and influenced by cellular processes.
    • Understanding these changes is crucial for comprehending cell cycle regulation and disease states.

    Purpose of the Study:

    • To review the sensitivity of chromatin structure to cellular proliferative states.
    • To investigate differences between normal and neoplastic cell chromatin.
    • To explore the utility of physiological stimuli in elucidating chromatin structure.

    Main Methods:

    • Analysis of chromatin structure across different cell cycle phases (mitosis, G1, S, G0).
    • Examination of chromatin in intact nuclei to rule out artifacts.
    • Assessment of the effect of low salt concentrations on chromatin structure.

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  • Comparison of chromatin from normal and neoplastic cells.

    • Main Results:

    • Chromatin structure and function exhibit significant sensitivity to the cell's proliferative state.
    • Differences in chromatin are detectable between various cell cycle stages (G0, G1, S, mitosis) and in intact nuclei.
    • Some observed chromatin differences can be reversed by low salt extraction.
    • Chromatin differences between normal and neoplastic cells are primarily linked to proliferation extent.

    Conclusions:

    • Cell proliferation profoundly impacts chromatin structure and function.
    • Chromatin changes during proliferation provide valuable insights into chromatin organization.
    • Investigating chromatin in proliferating cells offers a powerful approach to understand its structure and dynamics.