Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell surface proteins and malignant transformation

R O Hynes

    Biochimica Et Biophysica Acta
    |April 30, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Malignant cell transformation alters cell surface proteins, often reducing their amounts. Understanding these molecular changes in cell surface function is key to understanding cancer progression.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

    Leukemia·2017
    Same author

    Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.

    Oncogene·2016
    Same author

    Cellular and subcellular localization of LETS protein in the nervous system.

    Brain research·2011
    Same author

    Cell-matrix adhesion in vascular development.

    Journal of thrombosis and haemostasis : JTH·2007
    Same author

    Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2007
    Same author

    Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo.

    Journal of thrombosis and haemostasis : JTH·2006
    Same journal

    Cumulative Contents.

    Biochimica et biophysica acta·2020
    Same journal

    Molecular Basis of Disease Cumulative Contents.

    Biochimica et biophysica acta·2020
    Same journal

    General Subjects Cumulative Contents.

    Biochimica et biophysica acta·2020
    Same journal

    Erratum to 'on the role of exchangeable hydrogen bonds for the kinetics of P680<sup>+·</sup> Q<sub>A</sub> <sup>-·</sup> formation and P680<sup>+·</sup> Pheo<sup>-·</sup> recombination in photosystem II' [Biochim. Biophys. Acta 1276 (1996) 35-44].

    Biochimica et biophysica acta·2019
    Same journal

    Oligomeric state of the light-harvesting complexes B800-850 and B875 from purple bacterium Rubrivivax gelatinosus in detergent solution.

    Biochimica et biophysica acta·2019
    Same journal

    Regulation of pigment content and enzyme activity in the cyanobacterium Nostoc sp. Mac grown in continuous light, a light-dark photoperiod, or darkness.

    Biochimica et biophysica acta·2019
    See all related articles

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Cancer Research

    Background:

    • Malignant cell properties are linked to altered cell surface functions.
    • Understanding cell surface molecular structure is crucial for cancer research.

    Purpose of the Study:

    • To review methods for analyzing cell surface proteins.
    • To examine alterations in surface proteins of normal and transformed cells.
    • To discuss the functional implications of these molecular changes.

    Main Methods:

    • Analysis of cell surface proteins.
    • Comparison of protein profiles in normal versus transformed tissue culture cells.
    • Review of existing evidence on protein alterations and functions.

    Main Results:

    Related Experiment Videos

    • Cell transformation leads to changes in specific surface proteins.
    • Most alterations involve a reduction in protein quantity, with some increases observed.
    • Surface molecules exist in functional non-covalent complexes.

    Conclusions:

    • Cell surface protein alterations are a hallmark of malignant transformation.
    • These molecular changes impact cell function and cancer progression.
    • Further research into non-covalent complexes can elucidate physiological changes.