Related Experiment Video

Updated: Aug 9, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

Cell surface proteins and malignant transformation

R O Hynes

    Biochimica Et Biophysica Acta
    |April 30, 1976
    PubMed

    Insights

    Malignant cell transformation alters cell surface proteins, often reducing their amounts. Understanding these molecular changes in cell surface function is key to understanding cancer progression.

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Cancer Research

    Background:

    • Malignant cell properties are linked to altered cell surface functions.
    • Understanding cell surface molecular structure is crucial for cancer research.

    Purpose of the Study:

    • To review methods for analyzing cell surface proteins.
    • To examine alterations in surface proteins of normal and transformed cells.
    • To discuss the functional implications of these molecular changes.

    Main Methods:

    • Analysis of cell surface proteins.
    • Comparison of protein profiles in normal versus transformed tissue culture cells.
    • Review of existing evidence on protein alterations and functions.

    Main Results:

    • Cell transformation leads to changes in specific surface proteins.
    • Most alterations involve a reduction in protein quantity, with some increases observed.
    • Surface molecules exist in functional non-covalent complexes.

    Conclusions:

    • Cell surface protein alterations are a hallmark of malignant transformation.
    • These molecular changes impact cell function and cancer progression.
    • Further research into non-covalent complexes can elucidate physiological changes.

    More Related Videos

    Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics08:11

    Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

    Published on: March 26, 2018

    Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures08:02

    Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures

    Published on: July 27, 2022

    Related Concept Videos

    Cancer02:18

    Cancer

    Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
    Mitogens and the Cell Cycle02:38

    Mitogens and the Cell Cycle

    Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
    Abnormal Proliferation02:23

    Abnormal Proliferation

    Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
    Metastasis02:30

    Metastasis

    Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
    Epithelial-to-Mesenchymal Transition
    The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
    mTOR Signaling and Cancer Progression03:03

    mTOR Signaling and Cancer Progression

    The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
    The mTOR pathway or the...
    Cadherins in Tissue Organization01:19

    Cadherins in Tissue Organization

    The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
    Cell Sorting During Development
    Cell sorting plays an...