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The pathogenesis of hypertrophic/keloid scarring
D W Thomas1, I Hopkinson, K G Harding
1Department of Oral Surgery, Medicine and Pathology, Cardiff Dental School, UK.
International Journal of Oral and Maxillofacial Surgery
|August 1, 1994
Summary
Hypertrophic and keloid scars are common after skin injury, especially in maxillofacial surgery. This review covers scar formation factors and treatment options for these challenging lesions.
Area of Science:
- Maxillofacial Surgery
- Dermatology
- Wound Healing
Background:
- Hypertrophic and keloid scars frequently complicate cutaneous wound healing.
- These scar types present significant challenges in maxillofacial surgery.
- Understanding scar formation is crucial for effective management.
Purpose of the Study:
- To review the underlying factors contributing to hypertrophic and keloid scar formation.
- To outline current and potential therapeutic strategies for scar treatment.
- To provide an updated overview relevant to surgical practice.
Main Methods:
- Literature review of scientific publications.
- Synthesis of information on scar pathogenesis.
- Analysis of existing and emerging treatment modalities.
Main Results:
- Identified key local and systemic factors influencing scar development.
- Cataloged a range of treatments from conservative to surgical.
- Highlighted areas for future research and clinical application.
Conclusions:
- Scar formation is multifactorial, involving both local wound conditions and systemic influences.
- A comprehensive approach combining understanding of pathogenesis and diverse treatment options is necessary.
- Further research is needed to optimize scar management in surgical patients.