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Related Experiment Videos

Inhalation sedation with sevoflurane: a comparative study with nitrous oxide

N Haraguchi1, H Furusawa, R Takezaki

  • 11st Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan.

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
|January 1, 1995
PubMed
Summary

Sevoflurane shows promise for inhalation sedation, with patients reporting no adverse breathing experiences. All participants receiving sevoflurane indicated willingness for repeat procedures, suggesting good tolerability.

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Area of Science:

  • Anesthesiology
  • Respiratory Medicine
  • Pharmacology

Background:

  • Inhalation sedation is a common practice in medical procedures.
  • Nitrous oxide (N2O) is a widely used agent for inhalation sedation.
  • Exploring alternative agents for sedation is crucial for patient comfort and safety.

Purpose of the Study:

  • To assess the feasibility and patient acceptance of sevoflurane for inhalation sedation.
  • To compare sevoflurane with nitrous oxide (N2O) as agents for conscious sedation.

Main Methods:

  • Thirty-five volunteers were randomized into two groups: sevoflurane (n=20) and N2O (n=15).
  • Participants inhaled increasing concentrations of sevoflurane (0.1-0.3 MAC) or N2O (10-30%) with oxygen for 10 minutes each.
  • Respiratory and cardiovascular functions were monitored throughout the study.

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Main Results:

  • Both sevoflurane and N2O maintained stable respiratory and cardiovascular functions.
  • Five participants reported negative experiences with breathing N2O.
  • No negative comments regarding breathing were reported by participants receiving sevoflurane.

Conclusions:

  • Sevoflurane was well-tolerated by all participants during inhalation sedation.
  • All subjects in the sevoflurane group expressed willingness to undergo the procedure again.
  • Sevoflurane presents a potentially preferable alternative to N2O for inhalation sedation due to better patient acceptance.