Sleep patterns in depression and anxiety: theory and pharmacological effects

Sleep is invariably disrupted in patients who have depression and in patients with anxiety disorders. Depression and anxiety frequently coexist and are associated with disturbances in various neurotransmitters. The authors explore the relationship between sleep and the two disorders as well as the effects of antidepressants and anxiolytics on sleep architecture. The effects on sleep of various neurotransmitter systems implicated in depression and anxiety are outlined. Lastly, various theoretical models are proposed to account for the above mentioned phenomena and further directions for research are suggested.